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Nasuhidehnavi Lab

We are a dedicated research group exploring the intricate relationship between parasitic infections, chronic inflammation, and the acceleration of aging mechanisms. Our mission is to uncover how persistent infections and the body’s prolonged inflammatory responses contribute to age-related diseases, cellular degeneration, and overall aging. By examining the molecular processes at play, we aim to identify potential therapeutic interventions that could mitigate or delay the aging process, improving quality of life for aging populations worldwide. 

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Latest Publications

Emerging interactions between mitochondria and NAD+ metabolism in cardiometabolic diseases

Nicotinamide adenine dinucleotide (NAD+) is an essential coenzyme for redox reactions and regulates cellular catabolic pathways. An intertwined relationship exists between NAD+ and mitochondria, with consequences for mitochondrial function. Dysregulation in NAD+ homeostasis can lead to impaired energetics and increased oxidative stress, contributing to the pathogenesis of cardiometabolic diseases. In this review, we explore how disruptions in NAD+ homeostasis impact mitochondrial function in various cardiometabolic diseases. We discuss emerging studies demonstrating that enhancing NAD+ synthesis or inhibiting its consumption can ameliorate complications of this family of pathological conditions. Additionally, we highlight the potential role and therapeutic promise of mitochondrial NAD+ transporters in regulating cellular and mitochondrial NAD+ homeostasis.

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